Doctors say Pfizer’s Lyme disease vaccine trial results ‘encouraging’ after more than 70% efficacy shown

Doctors say Pfizer’s Lyme disease vaccine trial results ‘encouraging’ after more than 70% efficacy shown
Pfizer logo (Photo Illustration by Nikolas Kokovlis/NurPhoto via Getty Images)

(NEW YORK) -- Earlier this week, pharmaceutical company Pfizer and its partner Valneva announced that an experimental Lyme disease vaccine showed more than 70% efficacy in late-stage clinical trials.

The candidate, PF-07307405, showed 73.2% efficacy in reducing confirmed cases of Lyme disease cases after the fourth and final dose was administered when compared to a placebo.

However, the companies said there were fewer than anticipated cases of Lyme disease during the trial period and the study missed an important benchmark.

The trial did not reach its primary endpoint to provide an idea of how the results of this vaccine would turn out in a much larger population of people. Only with re-analyzing the data were researchers able to generate a statistically meaningful result.

Experts in tick-borne diseases told ABC News they still need to see the full data from the trials and that it's early to determine what kind of impact the vaccine will have -- but they add that results are "encouraging."

"There are many other companies that are trying to develop something, but those are years and years and years away from being anywhere close to being marketed," Dr. Gene Shapiro, a professor of pediatric infectious diseases and epidemiology of microbial diseases, told ABC News. "So, this vaccine was very similar to the vaccine that we know worked in the past. I think we have to pay attention to [this new one]."

Lyme disease is a bacterial infection that is spread through the bite of blacklegged ticks, also known as deer ticks, according to the Centers for Disease Control and Prevention (CDC).

Symptoms include fever, headache, fatigue and a skin rash known as erythema migrans, the CDC says. If left untreated, the infection can spread to joints, the heart and the nervous system.

More than 89,000 cases of Lyme disease were reported to the CDC by state health departments and the District of Columbia in 2023, according to the latest data available from the federal health agency. Estimates suggest about 476,000 Americans may be diagnosed and treated for Lyme disease annually.

Currently, no vaccine for Lyme disease is available in the U.S. Previously, a vaccine was available, but it was discontinued in 2002, according to the CDC.

"The uptake was poor. The sales were poor, and the company decided to stop selling it," Shapiro said. "The currently developed vaccine [by Pfizer and Valneva] is very, very similar to that vaccine, with very minor modifications."

Dr. Martin Becker, a clinical associate professor in the department of medicine at NYU Grossman Long Island School of Medicine, added that there were concerns raised, including about vaccine recipients having joint problems but several studies examining a link failed to find an association.

Becker said there have been many clinical trials underway "but this one that Pfizer just announced, I believe, is the one that's been most advanced," he told ABC News. "We were eagerly awaiting results from this large Phase III trial. Other previous trials were already published showing the safety and immunogenicity [of the vaccine]."

Pfizer and Valneva said they are planning to file for approval with the U.S. Food and Drug Administration, with Pfizer telling ABC News that the trial results show there is a level of protection against Lyme disease.

"It doesn't mean it doesn't work, but it does mean -- if we had higher numbers of incidence of infection -- we would be more confident about the degree of protection. It's very encouraging," Becker said.

Questions remain about whether the vaccine, if approved, will have higher uptake than the previous vaccine did decades earlier.

Shapiro said there might be more uptake with this vaccine if stronger recommendations are made. At the time the old vaccine was approved by federal regulators, Shapiro said the recommendation from the CDC's Advisory Committee on Immunization Practices was to consider the shot for those at higher risk, but it was not recommended for those at low or no risk.

"It was not a very strong recommendation," Shapiro said. "And I think there was less awareness of Lyme disease. So, most likely, [the newer vaccine] would get a stronger endorsement today."

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Sex offender arrested following search

Sex offender arrested following searchTYLER — A wanted sex offender out of Cass County was arrested on March 20 in Tyler following a coordinated search involving multiple state and federal law enforcement agencies. According to our news partner KETK, the Hughes Springs Police Department said that, Travion Holloman was previously convicted of aggravated sexual assault of a child but failed to comply with annual sex offender registration requirements.

A warrant for Holloman was issued in July 2025 out of the Cass County Sheriff’s Office.

On March 4, the police department contacted the Texas Department of Public Safety Criminal Investigation Division (DPS CID) to assist in locating Holloman. DPS CID coordinated with the DPS Homeland Security Division, the Texas Attorney General’s Office and the U.S. Marshals Fugitive Apprehension Task Force, who were able to locate Holloman in Tyler and take him into custody without incident.

Holloman also had additional outstanding warrants from several counties for probation violation related to the sexual assault case, evading arrest and possession of marijuana.

Palestine court scam

Palestine court scamPALESTINE — The Palestine Police Department is warning residents about a fraudulent document circulating in the community that falsely claims to be a court notice and attempts to collect payments.

According to our news partner KETK, officials said the fake “Notice of Default” appears to come from a municipal court and may include a QR code directing recipients to submit payment. Authorities emphasized that the document is a scam designed to create urgency and pressure individuals into sending money or sharing sensitive information.

Police urged residents not to scan the QR code, send payments or provide any personal or financial details in response to the notice.

“These notices are not legitimate,” the department said, adding that scammers are relying on fear and confusion to exploit victims.

Officials advised anyone who receives such a document to disregard it and instead verify any court-related matters directly with their local court. The department encouraged residents to report any suspicious documents to local law enforcement.

Man gets 35 years for murder

Man gets 35 years for murderMARSHALL – A Marshall man found guilty of murder and other charges related to a deadly shooting in 2024 was given a 35-year prison sentence on Monday. Curtis White, Jr., 19, started his 35-year prison sentence on Monday after being found guilty in the 71st District Court of murder, aggravated assault with a deadly weapon, and deadly conduct discharge of a firearm.

According to our news partner KETK, White was fined $10,000. On July 16, 2024, at approximately 11:50 a.m., a maroon car pulled up beside a white Nissan that was stopped at a red light on East Grand in Marshall. This led to the shooting. Before leaving the scene, White, the driver of the maroon car, fired into the Nissan, hitting the driver and a passenger.

The driver was taken to a nearby hospital with non-life-threatening injuries, while the passenger, Markel May, 20, died at the scene. White was taken into custody at the Harrison County Jail on a $1.2 million bond.

Man sentenced for arson/murder

Man sentenced for arson/murderTYLER – A man was sentenced to 45 years in prison on Monday, more than a year after he was arrested for allegedly dousing his girlfriend in gasoline and setting a Tyler house on fire. Following a report of a burning home, the Tyler Fire and Police Departments arrived at the 3300 block of Shady Trail on November 18, 2024, at approximately 3:37 a.m.

Our news partners at KETK report that Gregory Bargaineer, 67, entered the Smith County Jail twenty minutes later “to turn himself in for throwing gasoline on his girlfriend,” according to arrest records.

The body of Bargaineer’s alleged girlfriend, Marilyn Mceachin, was discovered on the floor close to the remains of a bed after the fire department extinguished the flames. Investigators were informed by Bargaineer that the victim had served him with an eviction notice the previous week. Continue reading Man sentenced for arson/murder

Grace girls soccer team honored

Grace girls soccer team honoredSMITH COUNTY -The Smith County Commissioners Court approved a resolution Tuesday, proclaiming March 24, 2026, as “Grace Community School Girls’ Soccer Day” to recognize the team winning the state championship.

The soccer team won the TAPPS All-Around State Championship on March 4, 2026. It was the second time in three years that they brought home the state title.
The girls were joined by dozens of family members and friends for the recognition in Commissioners Court.
Continue reading Grace girls soccer team honored

Fire out and shelter-in-place order is lifted after oil refinery explosion

PORT ARTHUR (AP) – An oil refinery fire near the Texas coast was put out Tuesday and a shelter-in-place order was lifted, hours after a large explosion at the complex shot plumes of smoke into the air, officials said.

No one was injured in Monday’s explosion at the Valero refinery in Port Arthur, about 90 miles east of Houston, Mayor Charlotte M. Moses said. She had urged residents in parts of the west side of the city to stay put.

“There’s been an explosion, yes, but we’re OK; everybody’s OK,” she said. “They’re trying to put the fire out as quickly as possible.”

Residents at least several miles away said they felt their homes shake. Some schools in the area were closed Tuesday as a precaution.

The explosion comes amid a spike in gas prices driven by uncertainty over the global oil supply because of the Iran war.

The refinery has about 770 employees and can process about 435,000 barrels of oil per day, according to Valero’s website. The plant refines heavy sour crude oil into gasoline, diesel and jet fuel.

Images and video posted online show a large plume of smoke and flames billowing out from the refinery.

Valero did not respond to emails and a call from The Associated Press seeking comment. Local television stations reported a company spokesperson said everyone was accounted for.

Texas state Rep. Christian Manuel said in a post on social media that the Texas Commission on Environmental Quality arrived at the refinery with air monitoring equipment and was working with local and state partners.

Abortion pills are gaining ground as a method for ending pregnancies, and opponents are responding

AUSTIN (AP) – As states that already ban abortion look to further restrict access this year, much of the focus is on pills sent by out-of-state providers.

A survey released Tuesday helps explain the emphasis. It suggests that more women in states with bans obtained abortions last year using the pills prescribed via telehealth than by traveling to places where it’s legal.

Most of the states with the political will to impose broad bans have already done so in the nearly four years since the U.S. Supreme Court overturned Roe v. Wade and opened the door to enforcing them. So far this year, just one state has a new one.

Here’s a look at where things stand as many state legislatures are wrapping up or have completed their 2026 sessions.

States are taking steps to make abortion pills harder to get

South Dakota Gov. Larry Rhoden, a Republican, signed a bill last week that makes it a felony to advertise, distribute or sell abortion pills.

Similar measures have cleared both legislative chambers in Mississippi this year. There, the House and Senate would need to iron out differences between their versions before it can be sent to the Republican Gov. Tate Reeves.

A survey of state abortion policies from the Guttmacher Institute, which supports abortion rights, finds that at least three states — Florida, Oklahoma and Texas — already have laws that specifically ban providers from mailing the pills to patients. Louisiana has classified one of the drugs, mifepristone, as a controlled dangerous substance.

Bills intended to keep out the pills have cleared one chamber of the legislature in Arizona, Indiana and South Carolina this year. Republicans control the legislatures in all three states and the governor’s office in two of them. But in Arizona, any restrictions that pass could be vetoed by Democratic Gov. Katie Hobbs.

Survey suggests abortion pills are a growing option in states with bans

A Guttmacher survey released Tuesday sheds light on why abortion opponents may be focusing on pills.

The report suggests that in 2025, for the first time, more women in the 13 states that ban abortion at all stages of pregnancy obtained pills through telehealth than traveled to other states for abortion.

The prescriptions come from providers in states with laws adopted since the fall of Roe that are intended to protect those who prescribe abortion pills to patients in states with bans.

The estimated increase in mailing pills comes as Guttmacher’s estimates also suggest fewer women are traveling to states like Colorado, Illinois, Kansas and New Mexico for abortion.

Guttmacher’s estimates are based on data from a monthly survey conducted among a random sample of U.S. abortion providers, combined with historical data from every provider in the U.S.

That follows a trend that’s been documented in other surveys of abortion providers.

Court battles are also centered on pills

Multiple states have court challenges to the federal rules that allow the abortion pill mifepristone to be prescribed via telehealth.

If they could require in-person prescriptions, it would at least dent the ability of out-of-state providers to get pills into places with bans in place.

Louisiana has such a lawsuit in federal court there; the attorneys general of Florida and Texas have one in Texas; those two states, along with Idaho, Kansas and Missouri, are making the same case in a Missouri court.

Meanwhile, Texas has filed civil cases and Louisiana criminal ones against providers accused of sending pills into their states.

The Food and Drug Administration last year approved a generic version of mifepristone, which frustrated abortion opponents.

One state imposed a ban, but its fate is uncertain

Wyoming is the only state this year that has imposed a new abortion ban.

Under a law signed in March by Republican Gov. Mark Gordon, it became the fifth state with a ban on abortion at about six weeks’ gestational age — before many women realize they’re pregnant. Like most of the others, Wyoming’s ban is on abortions once cardiac activity can be detected.

Courts have rejected previous Wyoming efforts to limit abortion.

The Wyoming Supreme Court in January struck down a ban on abortion at all stages of pregnancy.

The idea of punishing women is not gaining ground

No state has adopted a measure intended to allow criminal prosecutions against women who have abortions.

Proposals to do so keep getting made but sputter early in the legislative process.

The farthest such a bill has made it was a hearing last year before a Senate subcommittee in South Carolina. One was scheduled for a subcommittee hearing in Tennessee this month, but didn’t get one.

Pregnancy Justice, which advocates for the rights of pregnant people, says it’s tracked new “abortion-as-homicide” measures introduced in six states in 2026 — down from 13 states last year.

The major established anti-abortion groups oppose the approach. “Women require compassion and support,” said Ingrid Duran, the state legislative director for National Right to Life. “Not prosecution.”

Melissa Murray, a professor at New York University School of Law, says that introducing bills with penalties against women can break down the idea that such policies are off-limits.

“You keep pushing the boundary, pushing the envelope, eventually you will get what you’re seeking,” Murray said. “It will no longer feel fanciful or shocking.”

She also noted that women are already sometimes charged with crimes related to their pregnancies. This month, police in Georgia charged a woman with murder after allegedly using an abortion pill and the opioid painkiller oxycodone.

Abortion will be on ballots in November

Abortion questions will be before voters in at least three states in November.

Missouri lawmakers are asking voters to repeal the right to reproductive freedom that they put into the state constitution in 2024.

Elsewhere, voters are being asked to add constitutional amendments that largely mirror current state abortion laws.

In Nevada, a state constitutional amendment to allow abortion until fetal viability — generally considered to be sometime after 21 weeks of pregnancy — passed in 2024. But it needs voter approval a second time to take effect.

A Virginia measure on the ballot would guarantee the right to reproductive freedom, including access to contraception and making decisions on abortion care during the first two trimesters of pregnancy.

Large oil refinery explosion near Texas coast forces residents to shelter in place

A large explosion at an oil refinery near the Texas coast on Monday shot plumes of smoke into the air and forced nearby residents to shelter in place, officials said.

No one was injured in the explosion at the Valero refinery in Port Arthur, about 90 miles (145 kilometers) east of Houston, Mayor Charlotte M. Moses said. She urged residents in parts of the west side of the city to stay put, saying firefighters had arrived.

“There’s been an explosion, yes, but we’re OK; everybody’s OK,” she said. “They’re trying to put the fire out as quickly as possible.”

The explosion comes amid a spike in gas prices driven by uncertainty over the global oil supply because of the Iran war.

The refinery has about 770 employees and can process about 435,000 barrels of oil per day, according to Valero’s website. The plant refines heavy sour crude oil into gasoline, diesel and jet fuel.

Images and video posted online show a large plume of smoke and flames billowing out from the refinery. Some residents reported hearing a loud boom and seeing their windows shake.

“For your safety please remain in place until the ‘All Clear’ is given by emergency personnel,” the City of Port Arthur said in a post on its Facebook page.

Valero did not respond to an email or call from The Associated Press seeking comment.

Texas state Rep. Christian Manuel said in a post on social media that the Texas Commission on Environmental Quality had arrived at the refinery with air monitoring equipment and was working with local and state partners.

He told nearby residents to stay inside.

“Please limit outdoor activity, keep windows and doors closed, and follow guidance from local officials,” he said.

East Texas breeder faces federal charges after dog killing video unravels deplorable conditions at facility

HOPKINS COUNTY, Texas (KETK) — Months after a video surfaced of an East Texas breeder shooting a dog, a federal investigation revealed deplorable conditions at her unlicensed facility — charges that could send her to prison for up to 20 years.

An indictment delivered from a federal grand jury in the Eastern District of Texas on Monday names Kristine Michelle Hicks, 51, of Cumby and charged her with acting as an unlicensed animal dealer and four counts of wire fraud.

Hicks’ appearance in federal court comes after being arrested on Dec. 21, 2025, for a social media video depicting her allegedly shooting at a dog three times and leaving it for dead, spurring an investigation into her breeding facilities.

Following Hicks’ arrest, search warrants executed in Jan. 10 at her dog breeding and sale business, Giant German Shepherds, found 88 German shepherds held in devastating conditions.

“The dogs had lacked adequate shelter from environmental exposure in their pens,” the indictment said. “Their pens, dirt and mud filled, had rusty buckets clipped to fences in a crowded row that were supposed to be the dogs’ source of food. A few had some kibble in the bottom, but many were empty, and water containers had mostly dirty water in them.”

Dogs were found starving, sick and neglected — many had bite wounds, scars or feces caked on their coats and feet.

An approximate total of 131 dogs were held at the property in December 2025, but Hicks had moved some to another location. Various animal care agencies assisted the remaining 88 dogs, 56 of which were surrendered to the SPCA of Texas for emergency intervention.

Additionally, the investigation into Giant German Shepherds found that Hicks has been running the business fraudulently. She advertised dogs as healthy, met certified parentage and were American Kennel Club (AKC) registered though the indictment found that they were not.

Many of the dogs sold were mixed breeds — not the “purebred” promised on Hicks’ website — and had diseases, the indictment said. Hicks also bought litters through Facebook and allegedly created false AKC documents to defraud buyers.

Four people identified as victims of Hicks’ alleged wire fraud were named in the indictment, including a disabled veteran who received an aggressive dog with false paperwork. The dog, which had medical issues, reportedly drew blood from the buyer several times.

The indictment also states that Hicks knowingly violated the Animal Welfare Act by not obtaining a license from the Secretary of the Department of Agriculture before selling or transporting dogs from June 2024 to December 2025.

If convicted, Hicks could face up to 20 years in federal prison for her count of acting as an animal dealer without a license and four counts of wire fraud.

ICE’s 287(g) may get new member

ICE’s 287(g) may get new memberWHITEHOUSE — The City of Whitehouse is set to discuss joining ICE’s 287(g) program during Tuesday’s city council meeting. Council members will consider and potentially take action on entering the agreement after the Department of Homeland Security invited the city to participate in the task force.

According to our news partner KETK, joining the program would give local officers the authority, under ICE supervision, to arrest individuals who are in violation of federal immigration laws. Officials emphasized that this would not change their current arrest procedures or alter day?to?day operations. If approved, the city estimates it could receive up to $1.1 million within the first 12 months.

Under the task force model, participating officers can exercise limited immigration authority while performing routine duties, such as determining a person’s immigration status during a traffic stop or DUI checkpoint and sharing that information with ICE. Officers may also assist directly in ICE?led operations.

Wreck on I-20 in Waskom cleared

Wreck on I-20 in Waskom clearedWASKOM – Interstate 20 eastbound has reopened after it was blocked due to an 18-wheeler crashed in Waskom on Monday. The Waskom Police Department said an 18-wheeler and a vehicle crashed on I-20 eastbound near mile marker 633 at around 3:26 p.m. According to Waskom PD, all eastbound traffic is currently being directed onto the exit 633 on-ramp.

School of nursing announces new dean

School of nursing announces new deanTYLER — The University of Texas at Tyler named Dr. Jenifer Chilton as the dean of the School of Nursing. Chilton has served as interim dean since 2025, according to a UT press release.

“A longtime and highly respected member of our School of Nursing faculty, she has served as interim dean, providing steady leadership,” said UT Tyler President Julie V. Philley, MD. “Dr. Chilton brings a spirit of innovation and collaboration, along with a deep commitment to the university’s mission.”

Chilton first served as a preceptor for UT Tyler community health students in 2004 and became a clinical instructor in 2007. Starting in 2021, Chilton served as the associate dean for academic affairs, playing a key role in advancing the school’s academic mission, improving student outcomes and fostering a collaborative environment for faculty and staff. Continue reading School of nursing announces new dean